Faq
13C Breath Test FAQ
Hp infection is closely related to chronic gastritis, peptic ulcer (gastric ulcer and duodenal ulcer), dyspepsia, gastric mucosa-associated lymphoid tissue lymphoma (MALT), and gastric cancer. Moreover, in 1994, the International Agency for Research on Cancer (IARC) listed it as a Group 1, Carcinogenic to humans.
- DOB: The deviation value of 13C abundance of sample gas and 13C abundance of baselinegas in a group of samples is relative to the thousandth change rate of 13C natural abundance. Clinically, the DOB value is used to determine whether the subject is infected with Helicobacter pylori.
- Abundance: refers to the proportion of an isotope in all natural isotopes of the element.
- Base air sample: breath sample collected before the subject took urea [13C] capsule.
- Sample gas sample: breath sample collected after the subject takes urea [14C] capsule.
Negative values are normal measurement errors, and typically, values do not exceed around -3. If an operator observes values exceeding -3, it is advisable to conduct a quality control check on the instrument to ensure its performance is normal.
14C Breath Test FAQ
Card-type instrument: In this device, the radioactive nuclides on the breath card decay and emit beta radiation, which upon reaching the detector, generates an electrical pulse signal. This signal is then processed through electronic circuits and a microcontroller. Based on a predetermined threshold value, the instrument provides the diagnostic result of the sample (negative/positive or indeterminate). The instrument simultaneously displays and automatically prints this result.
It is because the test results of the 14C instrument are relative values, that is, the background value (external environmental interference) must be deducted. In a certain environment, if the detection value of the instrument is less than or equal to the background value, then we stipulate that the detection value is always 0.
This is caused by the law of the “statistical fluctuation” of radioactive measurements. Statistical fluctuations are not caused by the inaccuracy of the measuring instrument, but by the inherent characteristics of the measured object. Radioactive decay is random. When measured with a radiation detector, the counts detected in a unit of time constantly fluctuate around an average value. This fluctuation is accidental, disordered, and random. It is an inherent characteristic of radioactive decay, demonstrating its randomness.
The statistical law of radioactivity measurement proves that the longer the measurement time, the closer the detected count is to the true value and the more accurate the measurement result is. The default measurement time is determined through a large number of measurement tests during the instrument development stage, taking into account both clinical detection efficiency requirements and clinical diagnostic accuracy requirements. Therefore, the measurement time should not be shortened generally.
The biological half-life of the 14C-Urea drug is about 6 hours. The mass of the 14C-Urea capsule taken for a 14C -Urea Breath Test is about 0.77 micrograms. According to the biological half-life, the drug can be eliminated from the body in about 2 to 3 days. Thus, it will not affect men and women preparing for pregnancy. If the subject is concerned, he or she can drink more water to promote metabolism and speed up the excretion of the drug.
6 hours. 14C -Urea remains in the body for a very short time. Urea is the final product of human metabolism and does not accumulate in the body. Its biological half-life is about 6 hours. Ingested urea can be basically excreted from the bladder within 2 days. If urea is broken down, it is exhaled from the respiratory tract in the form of carbon dioxide, which is excreted faster.
We are committed to making it easier to pursue good health by leveraging our more than 20 years of innovation in breath tests.
Call Us Anytime
Tel: +86-755-26619490
Fax: +86-755-26617554